Statistical analyses were performed with the spss v. In this european randomised openlabel clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of 34. View serena battaglias profile on linkedin, the worlds largest professional community. Founded in 1996 by the current president jacques martel, editions atma international today collaborates with more than fifty authors and lecturers throughout europe and north america. Jacques demotesmainard director general ecrin anurupa dev lead specialist, science policy association of american medical colleges. Join facebook to connect with jacques delmote and others you may know. View the profiles of people named jacques delamotte. Ecrin is a notforprofit organisation that supports the conduct of independent, multinational clinical trials. Campus regulatory and ethical database, medical device outcome measure database director general prof. This figure, however, might be underestimated because it does not fully take into account the whole spectrum of longterm sequelae caused by infections 3. Jacques demotes mainard director general ecrin european. Ecrin consists of integrating national clinical research facilities into a euwide network, able to provide support to clinical research in any medical field, and for any type of clinical research through information and consulting, and through a set of flexible services for the conduct of multinational clinical studies. Design and methods this was a consensusbuilding process among the members of a multistakeholder task force, involving a wide range of experts.
Sign up for your own profile on github, the best place to host code, manage projects, and build software alongside 40 million developers. A high proportion of unipolar and bipolar type ii patients can present a depressive mixed state dmx. Esfri roadmap preparation, construction and operation of the infrastructure supporting multinational clinical trials in the eu. Neutral pictures also triggered a stronger startle reflex in normothymic bipolar patients compared to controls f3,123 3. Selection of creamy ganaches, black or milk pralines and sweets revisited. Cg and jw are members of the copenhagen trial units task force to develop theory and software for doing trial sequential analysis. Ecrin european clinical research infrastructures network. Jacques demotes, ecrin director jacques demotes mainard is neurologist and professor of cell biology, after an initial training in mathematics and computer science ba, molecular biology and neuroscience master degree, medicine md, neurologist, a. Creating a single european area for clinical research. Ecrin european clinical research infrastructure network impact on health and economy jacques demotes jacques. They incur substantial economic costs through direct and indirect healthcare and welfare spending, and via productivity losses, all of which substantially affect european development. Demotes mainard j, ohmann c, gluud c, chene g, fabris n, garattini s, lafolie p, carne x.
Born in montreal into a merchant family, montigny first saw military action as a volunteer on the expedition against schenectady in 1690. It is estimated that infectious diseases represent roughly 10% of the total burden of disease in the european union eu 1, 2. Survey on the deployment model of a clinical data management. Sharing and reuse of individual participant data from. Ecrin eric services offered include trial preparation, trial management, quality assurance, access to databases e.
See the complete profile on linkedin and discover jeanjacques connections and jobs at similar companies. Scientists are also urging policymakers to invest in. Objectives we examined major issues associated with sharing of individual clinical trial data and developed a consensus document on providing access to individual participant data from clinical trials, using a broad interdisciplinary approach. Jeanjacques daems key account manager b2b indirect. Specific barriers to the conduct of randomised clinical trials within rare diseases the europeean clinical research infrastructure ecrin perspective trials, 2016 to be submitted. Ecrin is a public, nonprofit organisation that links scientific partners and networks across europe.
The growing problem of antibiotic resistance represents a major health burden for the eu. View jacques demotes profile on linkedin, the worlds largest professional community. Pdf requirements for certification of ecrin data centres. European clinical research infrastructures network jacques demotes mainard jacques. Join facebook to connect with jacques delamotte and others you may know. Jun 15, 2017 interview with jacques demotes 15 june 2017 comments off on interview with jacques demotes this month two miror research fellows, maria olsen and mona ghannad university of amsterdam had the chance to interview jacques demotes, the director general of the european clinical research infrastructure network ecrin in paris. View the profiles of professionals named demotesmainard on linkedin. Evaluation of repositories for sharing individualparticipant. See the complete profile on linkedin and discover jacques.
The european clinical research infrastructures network ecrin is a distributed esfri european strategy forum on research infrastructures roadmap paneuropean infrastructure designed to support multinational clinical research, making europe a single area for clinical studies, taking advantage of its population size to access patients, and. Kappa is the leading provider of dynamic data analysis software, training and consulting services. Jacques demotes mainard s 105 research works with 1,827 citations and 7,215 reads, including. This feature may be linked to emotional dysregulation and is a potential endophenotype. This state is defined by an association of a major depressive episode with at least two specific hypomanic symptoms.
European development funds should be tapped to build research labs and biobanks in africa, according to a leading african research expert. View jacques izards profile on linkedin, the worlds largest professional community. Jacques demotes mainard, director general ecrin eric, european clinical research infrastructure network improve your managerial skills with ritrain program. Therapeutic hypothermia for acute ischaemic stroke.
Jacques demotes mainard ecrin claire devereux uk research and innovation rudolf dimper esrf technical infrastructure division peter doorn data archiving and networked services matthew dovey jisc suzanne dumouchel dariah alastair dunning 4tu. We sought to understand how such programmes are regulated in ten european union countries. Jacques demotesmainard clinical research plays a key role both in the development of innovative health products and in the optimisation of medical strategies, leading to evidencebased practice. Jacques demotes mainard inserm, paris, france ecrin 3 2008. Ensuring sustainability of software tools and services by cooperation with a research infrastructure. Emotional hyperreactivity in normothymic bipolar patients. We analysed the current landscape of data repositories to create a detailed description of available. Ecrin annual report european clinical research infrastructure network ecrin 2015 ecrin annual report 2015 our mission to support the conduct of multinational clinical trials in europe ecrin s vision is a society where decisions in medical practice are made based on sound scientific evidence from highquality clinical research. Ecrin european clinical research infrastructures network, a paneuropean infrastructure for clinical research. Typical investigational medicinal products follow relatively uniform regulations in 10 european clinical research infrastructures network ecrin countries.
Martine laville, severine pitel, cecilia martinho, snezana djurisic, jacques demotes mainard, christine kubiak, vittorio bertele, janus c. For 200 years, our black chocolate, milk or sweets revisited have an international reputation among gourmets. Mental health research priorities for europe the lancet. Normothymic bipolar patients displayed emotional hyperreactivity, mostly evidenced in neutral situations. Ecrin is supporting the development of a new cdms vista trials by eortc, which will only offer a saas based deployment model. Coordinated research infrastructures building enduring life. Steve canham contributing to a variety of eu and imi funded data focused projects in clinical research. Orchestrating differential data access for translational research. The european clinical research infrastructures network ecrin conducted a comprehensive survey on clinical research regulatory requirements, including questions on regulations of compassionate use programmes. Overview of threats to the validity of evidence and how to minimise them. Charles mgone, european and developing countries clinical trials partnership edctp, south africa and the netherlands daan du toit, minister counsellor science and technology.
Jacques demotes mainard, mdphdmba, is professor of cell biology, has a background in clinical neurology and a research curriculum as a basic neuroscientist, then as chair of a clinical research centre. Kastratovic1, christine kubiak2, jacques demotes mainard2 a 1 serbian medical society, belgrade, serbia 2 ecrin eric, european clinical research infrastructure network, 750 paris, france a summary topic explanation. Download citation on jan 1, 2009, jacques demotesmainard and others published ecrin integrating clinical research in europe. Jacques demotesmainard, mdphd, is a neurologist, professor of cell biology. We analysed the current landscape of data repositories to create a detailed description of available repositories and assess their suitability for hosting data from clinical studies, from the perspective of the clinical researcher. Proposed from 10 pieces, up to 84 pieces, for the very greedy allergens presence of nuts, milk, eggs, peanuts, gluten and soy. Jacques demotes mainard is neurologist and professor of cell biology, after an initial training in mathematics and computer science ba, molecular biology and neuroscience master degree, medicine md, neurologist, a. Data are analysed on whatever scale is available, from high frequency, high resolution transient data through low frequency, low resolution rate data in production analysis and on into full field history matching and vertical description using production log and formation test analysis. Survey on the deployment model of a cdms vista trials page 4 of 36 3 background the use of a specialist clinical data management systems cdms to handle the data that must be. Ecrin european clinical research infrastructure network. The european clinical research infrastructure network ecrin.
Evaluation of repositories for sharing individualparticipant data from clinical studies. Visiting professor jaques demotes executive masters in. Jacques demotes mainard, mdphd, is a neurologist, professor of cell biology. Facebook gives people the power to share and makes the world more open and connected. There is growing use, however, of saas or software as a service systems, in which the cdms is hosted externally by another organisation and access from the trials unit is webbased. European clinical research infrastructure network ecrin coordinator welcome prof. Using the best quality of clinical research evidence is essential for choosing the right treatment for patients. Data repositories have the potential to play an important role in the effective and safe sharing of individualparticipant data ipd from clinical studies. Ecrin was awarded in 20 the legal status of a european research infrastructure. Worked as a clinical neurologist and basic neuroscientist, then as director of a clinical investigation centre, and since 20 as director of the parisbased ecrin european clinical research infrastructure network, a research infrastructure supporting multinational clinical trials in europe. View jeanjacques daems profile on linkedin, the worlds largest professional community.
Implementing a system to enable credit for data sharing. Christine kubiak operations director chez ecrin european clinical research infrastructure. Authors kuchinke w, wiegelmann s, verplancke p, ohmann c. Extended cooperation in clinical studies through exchange of cdisc metadata between different study software solutions. Jacques demotes mainard director general ecrin anurupa dev lead specialist, science policy association of american medical colleges jeffrey drazen editorinchief new england journal of medicine rebecca english program officer national academies david fearon sr. A high proportion of unipolar and bipolar type ii patients can present a depressive. Jacques izard associate professor university of nebraska.1235 693 439 1459 251 353 1269 345 835 495 979 359 610 1231 1323 638 532 660 875 1037 52 857 110 1242 974 1110 392 902 173 435 906 1425 101 841 655 722 1325 629 1048 1148 496